What is it

Citrulline is a biological compound, a non-essential amino acid that intervinene in the urea cycle. Formed by transfer of the group from carbamoilo of the anhydride of phosphoric acid to the Group d-amino of ornithine which is also mitochondrial. It broadcasts from the mitochondria to the cytosol, where it continues the rest of the urea cycle.

What it is

It is a substance that produces a relaxation of blood vessels. In addition, to be converted by metabolism in an amino acid called arginine produces beneficial effects on the heart, the circulatory system and also benefits the immune system.
Citrulline has as main function to increase plasma levels of Arginine, but its importance lies in that she is able to cause incredible this amino acid increases in plasma much larger than if only arginine is taken alone. If it makes use of l-arginine in order to increase its production of ON (nitric oxide) it is better to think about combining with citrulline, which has risks for the Agency.
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Another important feature is that it helps us in the synthesis of muscle protein when we perform a protein diet. Indicates how Sergio Espinar, an expert in sports nutrition.

Its deficit may cause

The most common symptom of deficiency of citrulline is fatigue and continuing weakness of muscles. Although this condition may stem from other factors it is important to apply citrulline deficiency tests to monitor the levels of the vitamin in your body. Fatigue and stress are the main obstacles in achieving health and well-being. Therefore, test constant deficiency and vitamin testing will make sure you are on the right path to health and well-being.


As it is an amino acid that exists in a natural way, he is considered safe and there are no studies that indicate otherwise. However, not recommended in children, pregnant or breastfeeding, or in people with severe liver or kidney disease.

Dose of citrulline

A typical dose of this compound is between 6 and 18 grams a day. But delve deeper into this topic.

Foods containing citrulline

A good natural source of citrulline is watermelon and in fact the name comes from it. There are many more foods such as meat, fish, eggs, milk, beans, watermelon, melon and protein-rich foods. There are also food different supplements to help correct the deficiency in citrulline. It is important to take the recommended daily allowance of citrulline to prevent serious deficiency. This is important to add that taking citrulline in a natural way is impossible to exceed the recommended dose. You can eat alone. You can delve into the topic on our post. Also we leave you a video about a study of citrulline in watermelon.

Diseases in which its use can be recommended

Very preliminary studies in France at the end of 1970s insinuated that citrulline can improve mental function in people with Alzheimer's disease and also reduce overall fatigue and stress. However, these studies were not performed at the level of the modern scientific standards, and monitoring has not given them.

Where to buy

It is marketed mainly as citrulline malate or l-citrulline capsules mainly. We will dedicate a section of this website to bring you this product offers and recommendations.

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